Regulation of hematopoiesis by cytokines
| PAG Title | Regulation of hematopoiesis by cytokines |
| PAG ID | WIG000436 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | The process of hematopoesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the various hematopoietic cell types. Bone marrow stromal cells are the major source of hematopoietic cytokines in the non-infecteous state. In the presence of infection, cytokines produced by activated macrophages and TH cells induce hematopoietic activity. The induction by cytokines results in rapid expansion of the population of white blood cells to fight infection. The specific cytokines that affect a step of cell differentiation are placed adjacent to the arrow representing that step. Lines with ? indicate likely, but still hypothetical pathways. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 4,473 |
| Information Content | Rich |
| Other IDs | M5298 |
| Base PAG ID | WIG000436 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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